With a Presidential Inauguration taking place in the midst of a global pandemic, we have the opportunity to look at how past president's have dealt with pathogen outbreaks. Pre-antibiotic presidents faced illnesses in their personal lives alongside their fellow Americans, often with tragic results. Once vaccines were available, presidents often took leading roles to promote their use, both through public statements and through policy. But it was the very first president who actually took first-hand steps to stop an epidemic, steps that may have allowed for the very birth of our nation.